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US 2024/0158798 A1Published application
Non-viral gene/carrier complex for prevention or treatment of acute inflammatory disease
AssigneesIucf-Hyu (Industry-University Cooperation Foundation Hanyang University), Industry-University Cooperation Foundation Hanyang University Erica Campus
InventorsYong-Hee KIM, Ji Eun LEE, Ju Hyeong HONG, Chul-Su YANG
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Abstract
The present invention relates to a gene/carrier complex having the effect of preventing or treating acute inflammatory disease, comprising a tumor necrosis factor-alpha converting enzyme (TACE) siRNA and a non-viral gene carrier, wherein the non-viral gene carrier comprises a TFA salt of TKPR-oligo-arginine.
Claims18
A gene/carrier complex, comprising:
- siRNA that suppresses the expression of tumor necrosis factor-α converting enzyme (TACE);
- and
- a non-viral gene carrier,
- wherein the non-viral gene carrier includes tuftsin peptide-oligoarginine.
1 more element
A method of preparing a gene/carrier complex, comprising:
- mixing siRNA that suppresses the expression of tumor necrosis factor-α converting enzyme (TACE) and a non-viral gene carrier,
- wherein the non-viral gene carrier includes tuftsin peptide-oligoarginine.
Dependencies are inferred from the claim text.