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US 2024/0158770 A1Published application
Pde5a destabilizing domains
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsThomas J. Wandless, Ling-Chun CHEN, Yusaku MIYAMAE
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Abstract
Disclosed herein are systems, methods, and compositions for rapidly and reversibly destabilizing a target protein in vitro or in vivo, in the presence or absence of a cell-permeable, synthetic molecule or ligand.
Claims6
A destabilizing domain, comprising a region or a portion of human PDE5A wherein the stability-affecting protein domain is identified by introducing a predetermined amino acid into one or more selected sequence positions in a predefined region of the protein by walk through mutagenesis.
Dependencies are inferred from the claim text.