Recombinant polypeptide having acyl-coa compound reducing activity

A recombinant microorganism comprising:

• a pathway for producing at least one selected from the group consisting of 5-formylpentanoic acid, 6-aminocaproic acid, 1,6-diaminohexane, 6-hydroxyhexanoic acid, hexanedial, 6-aminohexanal, 6-hydroxyhexanal, and 1,6-hexanediol;
• and
• an exogenous nucleic acid sequence encoding an enzyme having an amino acid sequence set forth in SEQ ID NO:
• 1 or an enzyme having an amino acid sequence having a sequence identity of 60% or higher, 65% or higher, 70% or higher, 75% or higher, 80% or higher, 85% or higher, 88% or higher, 90% or higher, 93% or higher, 95% or higher, 97% or higher, 98% or higher, or 99% or higher with the amino acid sequence set forth in SEQ ID NO:
• 1 and having a reducing activity R of converting CoA thioester of an acyl-CoA compound into an aldehyde group.

A recombinant polypeptide comprising:

• (a) an amino acid sequence A having a sequence identity of 85% or higher, 88% or higher, 90% or higher, 93% or higher, 95% or higher, 97% or higher, 98% or higher, or 99% or higher with an amino acid sequence set forth in SEQ ID NO:
• 1;
• (b) a substitution of at least one amino acid at a position corresponding to a substrate-binding site of a polypeptide having an amino acid sequence set forth in SEQ ID NO:
• 1 in the amino acid sequence A;
• and
• (c) a reducing activity R of converting CoA thioester of an acyl-CoA compound into an aldehyde group.