Microneedle device for control of thyroid hormone levels
AssigneeEquilibrate Therapeutics, LLC
InventorElizabeth A. McAninch
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Abstract
Described is a microneedle device, preferably a controlled release device, for delivery of liothyronine (LT3 or salt thereof) to a patient with hypothyroidism and/or who is not pregnant. The microneedle device contains LT3 or salt thereof in an effective amount to maintain normal, stable levels, in the serum, of free and/or total T3. The microneedle device includes at least two components: multi-dimensional array of microneedle(s) and a substrate to which the base of the microneedle(s) are secured or integrated. The microneedles contain LT3 or salt thereof as well as a biodegradable and/or biodissolvable polymer, such as polyvinyl pyrrolidone for controlled release of LT3 or salt thereof. Also described are methods of making and using the microneedle device.
Claims26
A microneedle device comprising
- a) a plurality of microneedles each having a base end and a tip;
- b) a substrate to which the base end of the microneedle is secured or integrated;
- and
- c) an effective amount of liothyronine (LT3) or a salt thereof when administered transdermally to maintain:
- (i) stable serum levels of free or total T3, preferably total T3, T4, preferably free T4, or both,
- (ii) normal serum free T3:free T4 ratio,
- (iii) normal serum total T3:free T4 ratio,
- (iv) normal serum levels of thyroid stimulating hormone (TSH), or
- (v) a combination of (i), (ii), (iii), and (iv);
- in a patient with hypothyroidism, wherein the patient is not a pregnant female or a female planning to be pregnant.
Dependencies are inferred from the claim text.