US 2024/0156974 A1Published application

Compositions and methods for modulation of antibody activity

OwnerJohn KARANICOLAS, Jittasak Khowsathit +3inventors

InventorsJohn KARANICOLAS, Jittasak Khowsathit, Joseph Salvino, Daniel Pushparaju Yeggoni, Sven Miller

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Compositions and methods for modulating antibody activity are disclosed.

Dependent claims

A prodrug comprising an effector molecule and a protecting group,

wherein said effector molecule binds an allosteric antibody and increases or restores its binding activity,
wherein said protecting group comprises a substrate for a cleaving enzyme and a self-immolating linker, and
wherein said substrate for a cleaving enzyme is covalently attached to said effector molecule by said self-immolating linker.

Dependencies are inferred from the claim text.

A61K 47/65
The modifying agent being a protein, peptide or polyamino acid: peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
A61P 35/00
Antineoplastic agents
A61K 39/39541
Against materials from animals: against normal tissues, cells
A61K 47/542
The modifying agent being an organic compound: carboxylic acids, e.g. a fatty acid or an amino acid

From the US filing history. Foreign family members aren’t listed.

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