Baceriophage virus-like particles vaccines for chlamydia trachomatis infections
AssigneeUNM Rainforest Innovations
InventorsAMANDA L. COLLAR, KATHRYN MARIE FRIETZE
Life of this patent
Estimating the term…
Abstract
The present invention is directed virus-like particles (VLPs) which are useful in immunogenic compositions and vaccines epitopes mediating protection are disclosed. Immunogenic peptides are identified and are displayed on virus-like particles, especially Qbeta, MS2, or AP205 VLPs which provide a potent immunogenic response in a patient or subject and enhanced protection from Ct infection in a patient or subject. Pharmaceutical compositions and vaccines are disclosed as are methods for providing an immunogenic response and/or vaccinating a patient or subject against Chlamydia trachomatis infections.
Claims39
A composition comprising:
- (a) a virus-like particle (VLP) comprising a bacteriophage coat protein;
- and (b) at least one immunogenic peptide;
- wherein said peptide is displayed on said virus-like particle, and wherein said peptide comprises a conjugated antigenic determinant of at least five (5) contiguous amino acid residues of a peptide sequence according to SEQIDNOS:1-75.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
A composition comprising:
- (a) a virus-like particle (VLP) comprising a bacteriophage coat protein;
- and (b) at least one immunogenic peptide;
- wherein said peptide is displayed on said virus-like particle, and wherein said peptide comprises a conjugated antigenic determinant of a peptide sequence according any one of SEQIDNOS:1-75, wherein said bacteriophage coat protein is a dimeric Qbeta coat protein which conjugates said immunogenic peptide to lysine residues on the surface of said VLP.
Dependencies are inferred from the claim text.