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US 2024/0156874 A1Published application
Methods for generating stem cell-derived beta cells and uses thereof
AssigneePresident and Fellows of Harvard College
InventorsDouglas A. Melton, Jeffrey Robert Millman
Life of this patent
Estimating the term…
Abstract
Disclosed herein are methods for generating SC-β cells, and isolated populations of SC-β cells for use in various applications, such as cell therapy.
Claims20
-23. (canceled)
An in vitro composition that comprises a first agent, a second agent, and a plurality of cells that express PDX1 and NKX6.1, wherein the first agent and the second agent are not the same, wherein the first agent is SB431542, and wherein the second agent is a transforming growth factor-beta signaling pathway inhibitor.
A method comprising the step of:
- contacting an in vitro cell population comprising a plurality of cells that express PDX1 and NKX6.1 with a first agent and a second agent, wherein the first agent and the second agent are not the same, wherein the first agent is SB431542, and wherein the second agent is a transforming growth factor-beta signaling pathway inhibitor.
Dependencies are inferred from the claim text.