Compositions and methods for treating neurodegenerative disorders
AssigneesArizona Board of Regents on Behalf of the University of Arizona, The Trustees of Columbia University in the City of New York
InventorsRui Chang, Patrick T. Ronaldson, Qianying He, Wassim ELYAMAN, Elizabeth BRADSHAW, Kuixi ZHU
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Abstract
This invention relates generally to neurodegenerative diseases and conditions (e.g., Alzheimer's disease) characterized with dysfunctional energetic function, unregulated microglia phagocytic activity and other related de-regulated biological functions. This invention further relates to methods and compositions for treating such neurodegenerative diseases and conditions with pharmaceutical compositions capable of protecting neurons from cell death and unregulated microglia phagocytic activity.
Claims24
A method of treating a mammal suffering from a condition characterized with neuronal cell death, dysfunctional energetic function, unregulated microglia phagocytic activity, and/or other related de-regulated biological functions comprising
- administering to the mammal a composition comprising one or more agents capable of protecting neurons from cell death and unregulated microglia phagocytic activity,
- wherein the agent is selected from PEITC, an analog of PEITC, NAD+, NADH, NMN, NR, 7-methylsulfinylheptyl, 8-methylsulfinyloctyl, vitamin c, glutathione, and myrosinase,
- wherein the condition is one or more of a neurodegenerative disorder, aging, systemic inflammation, neuroinflammation, cancer, and diabetes,
- wherein the mammal is a human patient.
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A method of treating, preventing and/or ameliorating symptoms of a neurodegenerative disorder in a mammal in need thereof, the method comprising
- administering to the mammal an effective amount of an agent capable of protecting neurons from cell death and unregulated microglia phagocytic activity,
- wherein the agent is a pharmaceutical composition comprising a therapeutically effective amount of one or more of PEITC, an analog of PEITC, NAD+, NADH, NMN, NR, 7-methylsulfinylheptyl, 8-methylsulfinyloctyl, vitamin c, glutathione, and myrosinase,
- wherein the neurodegenerative disorder is selected from AD, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, motor neuron disease, subjective memory complaints, and MCI,
- wherein the mammal is a human patient.
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A composition comprising one or more of the following:
- PEITC, an analog of PEITC, NAD+, NADH, NMN, NR, a chemical moiety comprising isothiocyanate (e.g., 7-methylsulfinylheptyl, 8-methylsulfinyloctyl), vitamin c (ascorbate acid), glutathione, and myrosinase.
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Dependencies are inferred from the claim text.