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US 2024/0150792 A1Published application
Oncolytic Virus and Methods of Use
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Abstract
The present disclosure provides an oncolytic virus comprising a nucleic acid(s) encoding a granulocyte-macrophage colony-stimulating factor (GM-CSF) and a soluble form of the TGF-B receptor-II (sTGF-BRII). The present disclosure also provides compositions comprising the oncolytic virus and treatment methods using the oncolytic virus. The treatment methods include local and/or systemic administration of the oncolytic virus for treating cancers, such as solid tumors.
Claims31
An oncolytic virus comprising a nucleic acid encoding a granulocyte-macrophage colony-stimulating factor (GM-CSF) and a soluble form of the TGF-B receptor-II (sTGF-BRII).
Dependencies are inferred from the claim text.