Methods for the treatment of nash with advanced fibrosis and/or cirrhosis

A method for the treatment of non-alcoholic steatohepatitis (NASH) in a patient in need thereof, comprising administration of a double stranded RNAi (dsRNAi) oligonucleotide, or a pharmaceutically acceptable salt thereof, to the patient,

• wherein the dsRNAi oligonucleotide comprises an antisense strand and a sense strand, wherein the antisense strand and the sense strand form a duplex region, and wherein the antisense strand comprises a region of complementarity to a KHK mRNA target sequence;
• wherein the KHK mRNA target sequence comprises a nucleotide sequence selected from the group consisting of
• a) SEQ ID NO:
• 4 (KHK-885_ta);
• b) SEQ ID NO:
• 6 (KHK-1334_ta);
• c) SEQ ID NO:
• 1 (KHK-516_ta);
• d) SEQ ID NO:
• 2 (KHK-865_ta);
• e) SEQ ID NO:
• 3 (KHK-882_ta);
• and
• f) SEQ ID NO:
• 5 (KHK-1078_ta);
• and
• wherein the region of complementarity is fully complementary to the KHK mRNA target sequence, wherein the dsRNAi is capable of reducing ketohexokinase (KHK) expression and wherein NASH is in the advanced fibrotic and/or cirrhotic stage.