Anti-nkp30 antibody and application thereof
AssigneeShenghe (China) Biopharmaceutical Co., Ltd.
InventorsJinhua ZHOU, Cailin ZHU, Chongbing WU, Xiaoling JIANG, Liusong YIN
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Abstract
The present invention discloses an anti-NKp30 single domain antibody capable of activating the release of cytokines from NK cells or γδT cells, and a nucleic acid encoding the anti-NKp30 single domain antibody. The present invention also discloses a multifunctional fusion protein comprising the anti-NKp30 single domain antibody and a composition thereof, and the use in drugs for the treatment, prevention or diagnosis of diseases.
Claims28
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An anti-NKp30 single domain antibody comprising an immunoglobulin single variable domain, wherein the immunoglobulin single variable domain comprises complementary determining regions CDR1, CDR2 and CDR3, wherein,
- (a) CDR1, which is selected from any amino acid sequence of SEQ ID NOs:
- 47-69, 141 and 142, or a sequence having at least 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or more identity to any amino acid sequence of SEQ ID NOs:
- 47-69, 141 and 142, or an amino acid sequence having one or more (preferably 2 or 3) conserved amino acid mutations (preferably substitutions, insertions or deletions) compared to any amino acid sequence of SEQ ID NOs:
- 47-69, 141 and 142;
- (b) CDR2, which is selected from any amino acid sequence of SEQ ID NOs:
- 70-92 and 140, or a sequence having at least 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or more identity to any amino acid sequence of SEQ ID NOs:
- 70-92 and 140, or an amino acid sequence having one or more (preferably 2 or 3) conserved amino acid mutations (preferably substitutions, insertions or deletions) compared to any amino acid sequence of SEQ ID NOs:
- 70-92 and 140;
- (c) CDR3, which is selected from any amino acid sequence of SEQ ID NOs:
- 93-115, or a sequence having at least 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or more identity to any amino acid sequence of SEQ ID NOs:
- 93-115, or an amino acid sequence having one or more (preferably 2 or 3) conserved amino acid mutations (preferably substitutions, insertions or deletions) compared to any amino acid sequence of SEQ ID NOs:
- 93-115.
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The multifunctional fusion protein of claim 1724, wherein the cytokine is selected from IL8, IL10, IL15, IL18, TGF, VEGF, IFNγ, IFNα or GM-CSF.
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Dependencies are inferred from the claim text.