Constructs comprising single domain vhh antibodies against sars cov-2
AssigneeLumen Bioscience, Inc.
InventorsJames Michael ROBERTS, Benjamin JESTER, Mesfin Mulugeta GEWE, Nhi Yen KHUONG
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Abstract
The present disclosure relates to single domain antibodies (“VHHs”) against SARS-CoV-2, as well as to polypeptides comprising one or more of such VHHs. The disclosure also relates to nucleic acids encoding such VHHs and polypeptides; to methods of preparing such VHHs and polypeptides; to host cells expressing or capable of expressing such VHHs or polypeptides; to compositions comprising such VHHs, polypeptides, nucleic acids or host cells; and to uses of such VHHs, such polypeptides, such nucleic acids, such host cells or such compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
Claims15
1-43. (canceled)
A recombinant Spirulina, comprising:
- (a) a 5HVZ domain;
- and (b) an smAKAP domain.
An engineered polypeptide, comprising from N- to C-terminus, a first VHH antibody sequence;
- an smAKAP domain;
- and a second VHH antibody sequence.
Dependencies are inferred from the claim text.