Identification and Attenuation of the Immunosuppressive Domains in Fusion Proteins of Enveloped RNA Viruses
AssigneeISD Immunotech ApS
InventorsMogens RYTTERGAARD DUCH, Shervin BAHRAMI
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Abstract
The present invention relates to enveloped RNA viruses. The invention in particular relates to the generation of superior antigens for mounting an immune response by first identifying then mutating the immunosuppressive domains in fusion proteins of enveloped RNA viruses resulting in decreased immunosuppressive properties of viral envelope proteins from the viruses.
Claims14
(canceled)
A synthetic peptide comprising a dimeric form of an amino acid sequence, the amino acid sequence comprising a variant of SEQ ID NO:4, said variant differing from SEQ ID NO:4 at 1 or 2 or 3 point mutation(s), wherein each of said point mutation(s) consists of at least one exchange of an amino acid of SEQ ID NO:4 with another amino acid.
A synthetic peptide comprising a dimeric form of an amino acid sequence, the amino acid sequence comprising a variant of SEQ ID NO:214, said variant differing from SEQ ID NO:214 at 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 point mutation(s).
Dependencies are inferred from the claim text.