Covalent PPARG inverse-agonists

A compound of formula (I)

• wherein, independently from each occurrence
• R1 is selected from
• and * is the point of attachment to the nitrogen atom;
• R2 is selected from the group consisting of a halogen atom, and a —C═CH group;
• R3 is selected from the group consisting of a hydrogen atom, an C1-C3-alkyl group, and a halogen atom;
• R4 is selected from the group consisting of a hydrogen atom and a halogen atom;
• R5 is selected from the group consisting of a hydrogen atom and a halogen atom;
• R6 is selected from the group consisting of a hydrogen atom and a hydroxy(C1-C3)-alkyl group;
• R7, R7a is independently selected from the group consisting of a hydrogen atom, an C1-C3-alkyl group, a hydroxy group, a (C1-C3)alkoxy group, and a —CH2OCH2CH2R16 group;
• R, R8a is independently selected from the group consisting of a hydrogen atom and a halogen atom;
• R9 is selected from the group consisting of a hydrogen atom and a halogen atom,
• R10 is selected from the group consisting of a hydrogen atom and a phenoxy group;
• R11 is selected from the group consisting of a hydrogen atom, an C1-C3-alkyl group, a C1-C3-hydroxyalkyl group, a 3- to 6-membered heterocycloalkyl group comprising 1 or 2 heteroatoms independently selected from oxygen and nitrogen which is optionally substituted with a hydroxy group, a C1-C3-haloalkyoxy group, a C1-C3-haloalkyl group, a 5- to 6-membered heteroaryl group which is optionally substituted with a C1-C3-alkyl group, a —O—(C1-C3)-alkylen-OR17 group;
• R12 is selected from the group consisting of a hydrogen atom and a C1-C3-alkyl group;
• R13 is selected from the group consisting of a hydrogen atom, a halogen atom, a C3-C6-cycloalkyl group, a 4- to 6-membered heterocycloalkyl group comprising one heteroatom selected from oxygen or nitrogen, a C1-C3-haloalkyl group, a —O—(C3-C6-alkylen)-OH group, and a phenoxy group;
• R14 is selected from the group consisting of a hydrogen atom and a C1-C3-alkyl group;
• R15 is selected from the group consisting of a C1-C3-alkyl group and a halogen atom;
• R16 is selected from the group consisting of a C1-C3-alkyl group and a C1-C3-alkoxy group;
• R17 is selected from the group consisting of a hydrogen atom and a C1-C3-alkyl group;
• R18 is selected from the group consisting of a hydrogen atom and a halogen atom;
• or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.