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US 2024/0148869 A1Published application
Improved T cell receptor-costimulatory molecule chimera
OwnerJiasheng WANG, Li YU +7inventors
InventorsJiasheng WANG, Li YU, Lemei JIA, Yue LIU, Xueqiang ZHAO, Wei RUI, Zhixiao ZHOU, Guangna LIU, Xin LIN
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Abstract
The present invention relates to the field of biomedicine, to an improved T cell receptor-costimulatory molecule chimera, in particular to a T cell receptor (TCR) or TCR complex comprising a costimulatory molecule, a T cell comprising the TCR or TCR complex, and the use thereof.
Claims65
A modified T cell receptor (TCR) complex, wherein
- i) the TCR complex comprises a TCR α chain, a TCR β chain, CD3 ε, CD3 γ, CD3 δ and CD3 ζ;
- wherein at least one functional domain, such as a costimulatory molecule endodomain, is connected to the C-terminal of at least one of the TCR α chain, TCR β chain, CD3 ε, CD3 γ, CD3 δ and CD3 ζ;
- wherein the TCR α chain comprises a first target binding region and a first constant region, and the TCR β chain comprises a second target binding region and a second constant region;
- or
- ii) the TCR complex comprises a TCR γ chain, a TCR δ chain, CD3 ε, CD3 γ, CD3 δ and CD3 ζ;
- wherein at least one functional domain is connected to the C-terminal of at least one of the TCR γ chain, TCR δ chain, CD3 ε, CD3 γ, CD3 δ and CD3 wherein the TCR γ chain comprises a first target binding region and a first constant region, and the TCR δ chain comprises a second target binding region and a second constant region,
- preferably, the target binding region is an antigen-binding region.
4 more elements
Dependencies are inferred from the claim text.