Skin microenvironment targeted delivery for promoting immune and other responses
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsLouis D. Falo, JR., Adriana Teresita Larregina De Morelli
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Abstract
Methods are provided for promoting, reducing, or desensitizing various immune responses by delivery of sub-immunogenic doses of an allergen, alone or with other agents, or by delivery of antigens and adjuvants to a cutaneous microenvironment of a subject. Microneedle arrays can be used in connection with this delivery.
Claims26
1-20. (canceled)
A method for promoting a pro-inflammatory and an adaptive immune response to provide a positive immunization against tumors and infectious diseases to a subject in need thereof, the method comprising:
- administering an antigen and at least one adjuvant in a cutaneous microenvironment of the subject, thereby promoting the pro-inflammatory and adaptive immune response in the subject.
A method for promoting an immune response to a subject in need thereof, the method comprising:
- administering an antigen and at least one adjuvant in a cutaneous microenvironment of the subject, thereby promoting the immune response in the subject.
A method for promoting an immune response to a subject in need thereof, the method comprising:
- administering an antigen and at least two adjuvants in a cutaneous microenvironment of the subject, thereby promoting the immune response in the subject.
A dissolvable microneedle array for transdermal insertion into a patient for promoting an immune response in a subject in need thereof, the dissolvable microneedle array comprising:
- a base portion;
- and
- a plurality of microneedles extending from the base portion and containing an antigen and at least one adjuvant.
Dependencies are inferred from the claim text.