Recombinant rsv vaccine: methods of making and using the same
AssigneeBlue Lake Biotechnology, Inc.
InventorsBiao HE, Hong JIN, Maria Cristina GINGERICH
Life of this patent
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Abstract
Compositions and methods of inducing an immune response in a subject having RSV comprising administering a pharmaceutical composition comprising a prophylactic vaccine against RSV infection, wherein the vaccine comprises a live recombinant canine parainfluenza (CPI) vector backbone engineered to express a RSV F protein.
Claims20
A viral expression vector comprising a parainfluenza virus 5 (PIV5) genome having a heterologous nucleic acid sequence with at least 95% sequence identity to SEQ ID NO:
- 1, wherein the viral expression vector expresses a heterologous polypeptide comprising a live recombinant canine parainfluenza (CPI) vector backbone engineered to express a RSV F protein as target antigen.
A pharmaceutical composition comprising a parainfluenza virus 5 (PIV5) viral expression vector having a heterologous nucleic acid sequence with at least 95% sequence identity to SEQ ID NO:
- 1, wherein the viral expression vector expresses a heterologous polypeptide comprising a live recombinant canine parainfluenza (CPI) vector backbone engineered to express a RSV F protein as a target antigen.
Dependencies are inferred from the claim text.