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US 2024/0140899 A1Published application
Smb separator for organic acid purification using a strong acid cation resin
AssigneeAmalgamated Research, Inc.
InventorsLily Crane, Peter V. Ferrero
Life of this patent
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Abstract
Systems and methods for enriching an organic acid from a fermentation broth containing residual color, salts, and carbohydrates using simulated moving bed (“SMB”) chromatography to produce a high purity organic acid extract is disclosed. One embodiment of the method purifies citric acid from a fermentation broth into two product streams: a first product stream rich in salt, color, and carbohydrate impurities, and a second product stream comprising an extract enriched in organic acid.
Claims16
A process for purifying an organic acid comprising:
- separating an organic acid from a fermentation broth (FB) by adding an acid to the FB to form protonated organic acid;
- creating a solution of dissolved solids from the protonated organic acid;
- processing the solution of dissolved solids by using it as feedstock in a simulated moving bed (SMB) chromatography system that uses a dilute acid as an eluent and a strong acid cation (SAC) exchange resin;
- and
- wherein each step of the SMB chromatography system is divided into two sub-periods wherein a first sub-period encompasses a span of time where the feedstock and the eluent are injected into distinct columns within a recirculation loop and, concurrently, extract and raffinate fractions are also withdrawn from the SMB chromatography system at defined points and during a second sub-period an internal solids profile is recirculated within the SMB chromatography system without any additional material added or removed.
2 more elements
A system for purifying an organic acid comprising:
- a simulated moving bed (SMB) chromatography system for processing a solution of dissolved solids by using it as feedstock and that uses a dilute acid as an eluent, a strong acid cation (SAC) exchange resin;
- and
- wherein each step of the SMB chromatography system is divided into two sub-periods wherein a first sub-period encompasses a span of time where the feedstock and the eluent are injected into distinct columns within a recirculation loop and, concurrently, extract and raffinate fractions are also withdrawn from the SMB chromatography system at defined points and during a second sub-period an internal solids profile is recirculated within the SMB chromatography system without any additional material added or removed.
Dependencies are inferred from the claim text.