Modulators of g protein-coupled receptor 88

A compound of Formula (I) or a pharmaceutically acceptable salt thereof:

• wherein:
• i) -L- is selected from the group consisting of
• Ring A is selected from the group consisting of:
• a 5-10 membered cycloalkyl, a 5-10 membered cycloalkenyl, a 5-6 membered aromatic ring system, a 5-6 membered heteroaromatic ring system, an 8-membered bicyclic heterocyclic ring system and an 8-10 membered bicyclic heteroaromatic ring system;
• Ring B is selected from the group consisting of:
• a 5-8 membered cycloalkyl, a 5-6 membered aromatic and a 5-6 membered heteroaromatic ring;
• Ring C is selected from the group consisting of:
• a 5-6 membered aromatic and a 5-6 membered heteroaromatic ring;
• m is 0, 1 or 2;
• n is 0, 1 or 2;
• p is 0, 1 or 2;
• R1 is selected from the group consisting of:
• hydrogen, substituted or unsubstituted C1-C4 alkyl, substituted or unsubstituted C3-C4 cycloalkyl and substituted or unsubstituted C3-C4 cycloalkyl C1-C2 alkyl;
• wherein each substituent is independently selected from the group consisting of —ORc, nitrile or halo;
• wherein each Rc is independently selected from the group consisting of H, Me, Et and cyclopropyl;
• R2 is selected from the group consisting of:
• substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C2-C6 alkynyl;
• substituted or unsubstituted C3-C6 cycloalkyl;
• substituted or unsubstituted C1-C6 alkoxy, substituted or unsubstituted C3-C6 cycloalkoxy;
• substituted or unsubstituted C1-C6 alkoxy-C1-C6 alkyl;
• substituted or unsubstituted C3-C6 cycloalkoxy-C1-C6 alkyl;
• substituted or unsubstituted C1-C6 haloalkyl, substituted or unsubstituted C2-C6 haloalkenyl, substituted or unsubstituted C2-C6 haloalkynyl;
• substituted or unsubstituted C3-C6 cyclohaloalkyl;
• substituted or unsubstituted C1-C6 haloalkoxy, substituted or unsubstituted C3-C6 cyclohaloalkoxy;
• substituted or unsubstituted C1-C6 haloalkoxy-C1-C6 alkyl, substituted or unsubstituted C3-C6 cyclohaloalkoxy-C1-C6 alkyl, substituted or unsubstituted C1-C6 alkoxy-C1-C6 haloalkyl, substituted or unsubstituted C3-C6 cycloalkoxy-C1-C6 haloalkyl, substituted or unsubstituted C1-C6 haloalkoxy-C1-C6 haloalkyl, substituted or unsubstituted C3-C6 cyclohaloalkoxy-C1-C6 haloalkyl, —SO2Rd, and —NReRe;
• wherein Rd is C1-4 alkyl;
• wherein each Re is independently selected from the group consisting of H and C1-4 alkyl;
• wherein each substituent is independently selected from the group consisting of —ORe, ═O, —NReRe, nitrile, halo, C1-C4 alkyl, C1-C6 alkoxy, and a substituted or unsubstituted monocyclic, bicyclic or bridged 3-8 membered cycloalkyl or heterocycloalkyl ring, wherein each Re is independently selected from the group consisting of H and C1-4 alkyl;
• wherein each substituent of the monocyclic, bicyclic or bridged 3-8 membered cycloalkyl or heterocycloalkyl ring is independently selected from the group consisting of —OH, nitrile, halo, methyl or methoxy;
• each R3 is independently selected from the group consisting of:
• halogen, C1-C3 alkyl, C1-C3 haloalkyl, C1-C3 alkoxy, C1-C3 haloalkoxy or —CN;
• each R4 is independently selected from the group consisting of:
• halogen, C1-C3 alkyl, C1-C3 haloalkyl, C1-C3 alkoxy, C1-C3 haloalkoxy or —CN;
• each R5 is independently selected from the group consisting of:
• halogen, C1-C3 alkyl, C1-C3 haloalkyl, C1-C3 alkoxy, C1-C3 haloalkoxy, —CN, or θ-C(O)NReRe;
• Ra and Rb are each independently selected from the group consisting of:
• hydrogen, halogen, C1-C6 alkyl, and C1-C6 alkoxy;
• or wherein Ra and Rb, together with the atom to which they are bonded, form a 3-membered to 6-membered cycloalkyl or heterocycloalkyl ring comprising —O— or —NRf—, wherein Rf is H or methyl;
• provided that the compound is not:
• or
• ii) -L-, Ring A, Ring B, Ring C, m, p, R2, R3, R5, Ra, Rb, Rc, Rd, Re and Rf are as defined above under i),
• R1 is a C1 or C2 alkylenyl residue,
• n is 1 or 2, and
• one R4 moiety is a C1 alkylenyl residue and, when present, the other R4 moiety is as defined above under i),
• wherein the C1 alkylenyl R4 moeity is bonded to a carbon atom in Ring A that is ortho to the carbon atom of Ring A having the amide residue, and, together with the atoms to which they are bonded, the R1 and R4 moieties form a 5- or 6-membered ring;
• and/or
• iii) -L-, Ring A, Ring B, Ring C, n, p, R1, R4, R5, Ra, Rb, Rc and Rf are as defined above under i),
• m is 1 or 2;
• R2 is selected from the group consisting of:
• substituted or unsubstituted —O—C1-2 alkylenyl, wherein the oxygen atom is connected to Ring B;
• wherein each substituent is independently selected from the group consisting of —OH, nitrile, halo, methyl or methoxy;
• one R3 moiety is an —O— residue and, when present, the other R3 moiety is as defined above under i);
• wherein, together with the atoms to which they are bonded, the R2 moiety and —O— R3 moiety form a 5- or 6-membered ring.