Systems and methods for personalized radiation therapy
AssigneeCvergenx, Inc.
InventorsJacob G SCOTT, Javier TORRES-ROCA
Life of this patent
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Abstract
Disclosed herein are methods for personalized treatment of individual patient tumors. A computer software configured to integrate with a radiation therapy treatment planning system is presented. The computer software is configured to: assign a radiation sensitivity index (RSI) of a subject's tumor based at least in part on expression levels of one or more signature genes in the tumor; calculate a recommended personalized radiation dosage (RxRSI) for the subject based at least in part on a pre-determined genomic adjusted radiation dose (GARD) value and the RSI; and provide, to the radiation therapy treatment planning system, the recommended RxRSI as a radiation therapy dose for a radiation plan.
Claims20
A computer software configured to integrate with a radiation therapy treatment planning system, the computer software being configured to:
- assign a radiation sensitivity index (RSI) of a subject's tumor based at least in part on expression levels of one or more signature genes in the tumor;
- calculate a recommended personalized radiation dosage (RxRSI) for the subject based at least in part on a pre-determined genomic adjusted radiation dose (GARD) value and the RSI;
- calculate a proposed RxRSI based for the subject based at least in part on the pre-determined GARD value and the RSI;
- compare the proposed RxRSI to a predefined standard of care dose range;
- assign the recommended RxRSI a value within the predefined standard of care dose range when the proposed RxRSI is within or below the predefined standard of care dose range;
- and
- provide, to the radiation therapy treatment planning system, the recommended RxRSI as a radiation therapy dose for a radiation plan.
A method of developing a personalized radiation treatment plan, the method comprising:
- assigning a radiation sensitivity index (RSI) of a subject's tumor based at least in part on expression levels of one or more signature genes in the tumor;
- calculating a recommended personalized radiation dosage (RxRSI) for the subject based at least in part on a pre-determined genomic adjusted radiation dose (GARD) value and the RSI;
- calculating a proposed RxRSI based for the subject based at least in part on the pre-determined GARD value and the RSI;
- comparing the proposed RxRSI to a predefined standard of care dose range;
- assigning the recommended RxRSI a value within the predefined standard of care dose range when the proposed RxRSI is within or below the predefined standard of care dose range;
- and
- providing the recommended RxRSI as a radiation therapy dose for a radiation plan.
A method of developing a personalized radiation treatment plan, the method comprising:
- assigning a radiation sensitivity index (RSI) of a subject's tumor based at least in part on expression levels of one or more signature genes in the tumor;
- calculating a recommended personalized radiation dosage (RxRSI) for the subject based at least in part on a pre-determined genomic adjusted radiation dose (GARD) value and the RSI;
- calculating a proposed RxRSI based for the subject based at least in part on the pre-determined GARD value and the RSI;
- comparing the proposed RxRSI to a predefined standard of care dose range;
- assigning the recommended RxRSI a value within the predefined standard of care dose range when the proposed RxRSI is within or below the predefined standard of care dose range;
- determining whether the recommended RxRSI is within a predefined standard of care dose range;
- and
- providing the recommended RxRSI as a radiation therapy dose for a radiation plan.
Dependencies are inferred from the claim text.