Engineered Biosynthetic Pathways for Production of Histamine by Fermentation
AssigneeZymergen Inc.
InventorsCara Ann TRACEWELL, Alexander Glennon SHEARER, Michael Shareef SIDDIQUI, Steven M. EDGAR, Nicolaus HERMAN, Murtaza Shabbir HUSSAIN
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Abstract
The present disclosure describes the engineering of microbial cells for fermentative production of histamine and provides novel engineered microbial cells and cultures, as well as related histamine production methods.
Claims24
An engineered microbial cell that comprises a non-native histidine decarboxylase, wherein the non-native histidine decarboxylase comprises at least 70% amino acid sequence identity with a histidine decarboxylase having SEQ ID NO:1 or SEQ ID NO:4, wherein the engineered microbial cell produces histamine in culture.
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Dependencies are inferred from the claim text.