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US 2024/0124531 A1Published application
Compounds and methods for extending half life of biomolecules
AssigneeAffilogic
InventorsMathieu CINIER, Olivier KITTEN
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Abstract
The invention relates to variants of OB-fold proteins, in particular of the Sac7d family that bind to human and mouse serum albumin and that can be used to increase serum half-life of elements associated therewith.
Claims20
A polypeptide comprising a variant of a member of a Sac7d family binding to human and mouse serum albumin, wherein the variant comprises from 4 to 20 mutated residues in an interface of binding of the member of the Sac7d family to its natural ligand, and wherein the variant comprises K22W, W24L, T33K, and R42Y mutations with numbering corresponding to positions in the Sac7d sequence of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.