Pectin Compositions and Methods of Use
AssigneeThe Brigham and Women S Hospital, Inc.
InventorSteven James Mentzer
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Abstract
The present disclosure describes bioadhesive polymer composition comprising: a first film comprising a polymer comprising: i) high-methoxyl pectin (HMP) and ii) an initial water content ranging from about 37% to about 43% (w/w); and a second film comprising a polymer comprising: i) HMP and ii) an initial water content ranging from about 9% to about 13% (w/w), wherein the first and second films are adhered to each other. Methods of preparing the bioadhesive polymer compositions and methods of sealing an ocular injury in an eye of a subject are also described.
Claims21
-31. (canceled)
A bioadhesive polymer composition comprising:
- a first film comprising a polymer comprising:
- i) high-methoxyl pectin (HMP) and ii) an initial water content ranging from about 37% to about 43% (w/w);
- and
- a second film comprising a polymer comprising:
- i) HMP and ii) an initial water content ranging from about 9% to about 13% (w/w),
- wherein the first and second films are adhered to each other, and
- wherein the first film is in a gel phase and the second film is in a glass phase.
A method of preparing a conjoined bioadhesive polymer composition, the method comprising:
- providing a first film comprising a polymer comprising:
- i) high-methoxyl pectin (HMP) and ii) an initial water content ranging from about 37% to about 43% (w/w);
- providing a second film comprising a polymer comprising:
- i) HMP and ii) an initial water content ranging from about 9% to about 13% (w/w);
- and
- compressing the first film and the second film, thereby producing the conjoined bioadhesive polymer composition,
- wherein the first film is in a gel phase and the second film is in a glass phase.
A method of sealing an ocular injury in an eye of a subject, the method comprising:
- providing a bioadhesive film comprising a polymer comprising:
- i) high-methoxyl pectin (HMP) and ii) water;
- and
- contacting the eye of the subject with the bioadhesive film;
- and
- applying pressure to the bioadhesive film, thereby sealing the ocular injury in the eye of the subject.
Dependencies are inferred from the claim text.