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US 2024/0123007 A1Published application
Hla-restricted vcx/y peptides and t cell receptors and use thereof
AssigneeBoard of Regents, The University of Texas System
InventorsCassian YEE, Ke PAN
Life of this patent
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Abstract
Provided herein are tumor-antigen VCX/Y specific peptides and engineered VCX/Y specific T cell receptors. Also provided herein are methods of generating VCX/Y-specific immune cells and their use for the treatment of cancer. In addition, the VCX/Y-specific peptides may be used as a vaccine.
Claims14
An isolated VCX/Y peptide of 35 amino acids in length or less comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO:
- 1, 8, 9, 12, 13, or 14, wherein the peptide is capable of inducing cytotoxic T lymphocytes (CTLs) and selectively binds to HLA-A2.
Dependencies are inferred from the claim text.