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US 2024/0117293 A1Published application
Monitoring System with Fiber Ripple Detection and Method
OwnerBryan A. Hassell, Gregory A. Phelps +1inventors
InventorsBryan A. Hassell, Gregory A. Phelps, David P. Marchessault
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Abstract
Devices for monitoring a bioreactor are configured for in-situ or ex-situ analysis. Noise from polarization dependent loss is addressed with a polarizer and reference photodetector for detecting a swept wavelength signal from a tunable laser spectrometer after transmission on a optical fiber but before a sample detection region.
Claims18
A monitoring system comprising:
- a tunable laser spectrometer for generating a swept wavelength signal for transmission on an optical fiber;
- a reference photodetector for detecting the swept wavelength signal from the tunable laser spectrometer after transmission on the optical fiber;
- a sample photodetector for detecting the swept wavelength signal after transmission through a sample detection region.
A monitoring system comprising:
- a tunable laser spectrometer for generating a swept wavelength signal;
- a reference photodetector for detecting the swept wavelength signal from the tunable laser spectrometer;
- a polarizer for improving a polarization of the swept wavelength signal prior to the reference photodetector;
- and
- a sample photodetector for detecting the swept wavelength signal after transmission through a sample detection region.
2 more elements
A probe for a bioreactor, comprising:
- ports defining a sample detection region in the bioreactor;
- a reference photodetector for detecting an optical signal received from a polarizer and prior to the sample detection region;
- and
- a sample photodetector for detecting the optical signal after transmission through the sample detection region.
1 more element
A method for on-line or off-line monitoring of a bioreactor, the method comprising:
- generating a swept wavelength signal;
- transmitting the swept wavelength signal to a sample detection region for a sample of the bioreactor;
- polarizing the swept wavelength signal;
- detecting the swept wavelength signal after polarization and prior to transmission through the sample detection region;
- detecting the swept wavelength signal after transmission through the sample detection region;
- and
- resolving an absorption spectra of a sample in the sample detection region with reference to the swept wavelength signal before and after transmission through the sample detection region.
4 more elements
Dependencies are inferred from the claim text.