Novel glutaminyl cyclase inhibitors and the use thereof in treatment of various diseases

-5. (canceled)

A method for treatment of a lung disease, a respiratory tract disease, or both comprising administering to a subject in need of treatment a therapeutically effective amount of a compound, wherein the compound is

• or a pharmaceutically acceptable salt, hydrate, or solvate thereof.

A method for treatment of a lung disease, a respiratory track disease, or both, comprising administering to a subject in need of treatment a daily dose of up to 0.5 g per day of a compound, wherein the compound is

• wherein the lung disease, respiratory track disease, or both, is selected from bronchial asthma, acute or chronic bronchitis, pharyngitis, lung emphysema, rhinitis, rhinosinusitis, chronic obstructive pulmonary disease, acute lung injury, pulmonary bronchitis, pneumonia, allergic rhinitis, sinusitis, pharyngitis.

A method for treatment of a lung disease, a respiratory track disease, or both, comprising administering to a subject in need of treatment a daily dose of up to 0.5 g per day of a compound, and the compound is introduced as individual compound, wherein the compound is

• wherein the lung disease, respiratory track disease, or both, is selected from bronchial asthma, acute or chronic bronchitis, pharyngitis, lung emphysema, rhinitis, rhinosinusitis, chronic obstructive pulmonary disease, acute lung injury, pulmonary bronchitis, pneumonia, allergic rhinitis, sinusitis, pharyngitis lung injury.

A method for treatment of a disorder associated with the activity of glutaminyl cyclase and/or aberrant activity of cells of the immune system, comprising administering to a subject in need of treatment a of formula IV

• or pharmaceutically acceptable salts, hydrates, or solvates thereof wherein the disorder selected from a group consisting of bronchial asthma, acute or chronic bronchitis, pharyngitis, lung emphysema, rhinitis, rhinosinusitis, chronic obstructive pulmonary disease, or acute lung injury, pulmonary bronchitis, pneumonia, allergic rhinitis, pulmonary emphysema, COPD, sinusitis, pharyngitis, non-infectious lung injury, fever, pain syndrome, obesity, psoriasis, atopic dermatitis, Crohn's disease, ulcerative colitis, and diabetic nephropathy.