Amiloride derivatives and methods of using same for the treatment of viral infections

A compound of Formula (I), a pharmaceutical acceptable salt, a hydrate, a prodrug, an ester, or a derivative thereof:

• wherein R1 and R2 are independently H, C1-C8 alkyl, substituted C1-C8 alkyl, C1-C8 alkenyl, substituted C1-C8 alkenyl, C3-C6 substituted cycloalkyl, a C3-C6 unsubstituted cycloalkyl, aryl, or substituted aryl;
• R3, and R4 are independently H, C1-C8 alkyl, substituted C1-C8 alkyl, C1-C8 alkenyl, substituted C1-C8 alkenyl, C3-C6 substituted cycloalkyl, a C3-C6 unsubstituted cycloalkyl, aryl, substituted aryl, or R3 and R4 may be taken together to form a C3-C6 substituted cycloalkyl, a C3-C6 unsubstituted cycloalkyl, C3-C6 substituted cycloalkenyl, a C3-C6 unsubstituted cycloalkenyl, a substituted heterocycle, a unsubstituted heterocycle, or a C3-C24 heteroaromatic;
• R5 is C1-C8 substituted alkyl, C1-C8 unsubstituted alkyl, C3-C6 substituted cycloalkyl, C3-C6 unsubstituted cycloalkyl, a substituted heterocycle, an unsubstituted heterocycle, C3-C24 aromatic, C3-C24 heteroaromatic,
• and
• R6, R7, R8, R9, R10, R11, R12, R13, and R14 independently are H, Cl, Br, F, CF3, C1-C6 substituted alkyl, C1-C6 unsubstituted substituted alkyl, OCH3, NH2, NHCH3, N(CH3)2, CN, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, or phenyl;
• and
• X is O, S, or NH.