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US 2024/0116865 A1Published application
Compounds for the treatment of sars
AssigneePurdue Research Foundation
InventorsArun K. Ghosh, Monika Yadav, Andrew Mesecar
Life of this patent
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Abstract
Inhibitors of SARS-CoV-2 (COVID), pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome.
Claims18
A compound of the formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is alkyl, —O-alkyl, -heterocyclyl, —O-heterocyclyl, —O-alkylene-heterocyclyl, —O-alkylene-aryl, -alkylene-heterocyclyl, —N(Ra)alkyl, —N(Ra)heterocyclyl, alkylene-O-heterocyclyl, alkylene-O-aryl, or -alkylene-N(H)C(O)CF3;
- each of which can be substituted with any suitable substituent, including halo, alkyl, alkoxy, alkoxyalkyl, and aminoalkyl;
- R2 is alkyl, aryl, substituted aryl;
- R3 is heterocyclyl or cycloalkyl;
- R4 is H, alkyl or alkenyl;
- and
- Ra is H or alkyl,
- or a pharmaceutically acceptable salt thereof.
6 more elements
Dependencies are inferred from the claim text.