Method and composition for the treatment of cancer
AssigneeAntiCancer, Inc.
InventorsYutaro Kubota, Qinghong Han, Robert Hoffman
Life of this patent
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Abstract
A composition and method for treating cancer in a subject in need thereof. The composition includes recombinant-methioninase-producing bacterial strains that upon oral administration can release recombinant-methioninase in the gut of the subject. The bacterial strains include Escherichia coli bacteria comprising the cloned rMETase gene from Pseudomonas putida using plasmid pATG3131, such as Escherichia coli JM109 strain. The bacteria can be incorporated in the microbiome of the subject and release the recombinant-methioninase.
Claims17
A method for treating cancer in a subject in need thereof, the method comprising:
- administering, orally, to a subject, a composition comprising recombinant methioninase producing bacterial strains in an effective amount to release recombinant methioninase in a gut of the subject.
A method of generating recombinant methioninase enzyme in a gut of a subject, the method comprises:
- administering, orally, to the subject, a composition comprising recombinant methioninase producing bacterial strains in an effective amount to release recombinant methioninase enzyme in the gut of the subject.
An oral composition for treating cancer in a subject in need thereof, the composition comprises:
- recombinant methioninase producing bacterial strains in an effective amount to release recombinant methioninase in a gut of the subject.
Dependencies are inferred from the claim text.