Ip4-4,6 substituted derivative compounds

A compound of general formula I:

• a pharmaceutically acceptable salt thereof, or a combination thereof, wherein
• (i) R1, R3, R7, and R11 independently represent OPO32−;
• R5 and R9 are substituent groups each one corresponding to the formula —O(Alkyl)nX, wherein n is an integer between 1 and 20, wherein the terminal group X is selected from the group consisting of —H, —OR, —NRR′, —COOR, —CONRR′, —NHCOR, —NHCOOR, —OCONR, —NHSO2R, —NHCONRR′, halogen, —CF3, carbocycle (saturated or unsaturated), and heterocycle (saturated or unsaturated), and wherein R and R′ are H or an alkyl group;
• (ii) R1, R3, R7, and R11 independently represent OPO32−;
• R5 and R9 are substituent groups each one corresponding to the formula —O(Alkyl)yCy(Alkyl)y-Z, wherein y is an integer between 0 and 10, wherein Cy is a cyclic linker, wherein the terminal group Z is selected from the group consisting of alkyl, —COR, —OR, —NRR′, —COOR, —CONRR′, —NHCOR, —NHCOOR, —OCONR —NHSO2R, —NHCONRR′, halogen, and —CF3, and wherein R and R′ are H or an alkyl group;
• (iii) R1, R3, R7, and R11 independently represent OPO32−;
• R5 and R9 are substituent groups each one corresponding to the formula —O(Alkyl)yA(Alkyl)y-Z′, wherein y is an integer between 0 and 10, wherein A is a linker selected from the group consisting of —CONR—, —NHCOO—, —NHSO2, —NHCONR—, —NHCO—, and —OCONR, wherein the terminal group Z′ is selected from the group consisting of —OR, —NRR′, —COOR, —CONRR′, —NHCOR, —NHCOOR, —OCONR, —NHSO2R, —NHCONRR′, carbocycle (saturated or unsaturated), heterocycle (saturated or unsaturated), and wherein R and R′ are H or an alkyl group;
• and
• (iv) the compound of formula I is an analog of (i), (ii) or (iii) wherein at least one of R1, R3, R7 or R1 is thiophosphate (—OPSO22−).