Method for diagnosis of neurodegenerative diseases by using hpma
AssigneeUniversity-Industry Cooperation Group of Kyung Hee University
InventorsMyung Sook Oh, Dong Hyun Kim, Jin Gyu Choi, Eugene Huh
Life of this patent
Estimating the term…
Abstract
The present invention relates to a composition for the diagnosis of a degenerative brain disease, comprising hpmA, which is a substance derived from Proteus, Shigella, Klebsiella pneumoniae, or Citrobacter, preferably a Proteus mirabilis strain, from a biological sample of a subject. In addition, the present invention relates to a method for providing information for the diagnosis of a degenerative brain disease such as Parkinson's disease, brain neuritis (neuroinflammation), or Alzheimer's disease, by measuring the amount of hpmA.
Claims21
A composition for the diagnosis of a degenerative brain disease, comprising hpmA.
A method for the diagnosis of a degenerative brain disease, comprising the step of measuring the amount of hpmA from a biological sample of a subject.
A composition for the preparation of an animal model of a degenerative brain disease, comprising a strain comprising an hpmA gene as an active ingredient.
A method for the preparation of an animal model of a degenerative brain disease, comprising the step of administering a strain comprising an hpmA gene to an animal excluding a human.
A method for screening a therapeutic agent for a degenerative brain disease, comprising:
- (a) the step of administering a candidate drug;
- (b) the step of measuring the amount of hpmA from a biological sample of a subject;
- and
- (c) the step of determining the therapeutic effect of a candidate drug.
Dependencies are inferred from the claim text.