Isolated double stranded dna polynucleotide
AssigneesUniversite De Lorraine, Centre National De La Recherche Scientifique
InventorsSylvain MAENNER, Isabelle BEHM-ANSMANT, Charbel ALFEGHALY
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Abstract
The present invention relates to an isolated double stranded DNA polynucleotide that forms triplex with sequence 5′-GGUGGCAGCAAGAGAAAAAUGAGGAAGAAGCAAAAGCGGAAA-3′ (SEQ ID NO: 1) of the long non-coding RNA ANRIL (Antisense Non-coding RNA in the INK4 Locus). It also relates to a vector comprising the double stranded DNA polynucleotide, and to a pharmaceutical composition comprising the double stranded DNA polynucleotide or the vector. The present invention relates as well to the isolated double stranded DNA polynucleotide for use in the treatment of myocardial infarction, aneurysms, stenosis, myocardial infarction, aneurysms, cancers, eye diseases or type 2 diabetes.
Claims16
An isolated double stranded DNA polynucleotide that forms triplex with sequence 5′-GGUGGCAGCAAGAGAAAAAUGAGGAAGAAGCAAAAGCGGAAA-3′ (SEQ ID NO:
- 1) of the long non-coding RNA ANRIL (Antisense Non-coding RNA in the INK4 Locus).
Dependencies are inferred from the claim text.