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US 2024/0101628 A1Published application
Cancer Treatment
AssigneeImperial College Innovations Limited
InventorsAmin Hajitou, Keittisak Suwan, Mariam Albahrani, Sajee Waramit
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AssigneeImperial College Innovations Limited
InventorsAmin Hajitou, Keittisak Suwan, Mariam Albahrani, Sajee Waramit
Estimating the term…
The present invention provides phagemid vectors and associated phagemid particles for cancer treatment, and in particular, to the use of novel phagemid particles and associated expression systems for the treatment, prevention, amelioration, or management of cancer. In particular, the invention relates to the use of phagemid particles and expression systems for the delivery of transgenes encoding cytokines, for the treatment, prevention, amelioration, or management of cancer. The invention also extends to the use of phagemid particles and expression systems for the delivery of transgenes, and for the combination of such treatment with the use of adoptively transferred T cells, for the treatment, prevention, amelioration, or management of cancer.
1-38. (canceled)
A recombinant phagemid particle comprising M13 phage coat proteins and a phagemid particle genome comprising a transgene expression cassette, wherein the transgene expression cassette comprises a promoter and a nucleic acid sequence encoding a protein, wherein the genome comprises no more than 50% of a bacteriophage genome and encodes neither a pIII capsid minor coat protein nor a pVIII capsid major coat protein.
Dependencies are inferred from the claim text.