Methods and compositions for modulating gene expression
AssigneeWisconsin Alumni Research Foundation
InventorsAseem Ansari, Graham Erwin, Matthew Grieshop
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Abstract
The present technology relates to compositions and methods for modulating expression of genes which include a target oligonucleotide sequence, such as repeats of a particular oligonucleotide sequence containing 3 to 10 nucleotides. In particular aspects, the present technology relates to agents having a formula A-L-B, wherein -L- is a linker; A- is a Brd4 binding moiety; and -B is a nucleic acid binding moiety, such as a polyamide or complementary oligonucleotide, that specifically binds to the target oligonucleotide sequence.
Claims24
A method for modulating transcription of a gene that comprises at least one oligonucleotide repeat comprising a sequence of CGG, CTG, or CCTG by contacting a cell comprising the gene with an agent having a formula A-L-B, wherein L is a linker, B is a nucleic acid binding moiety, and A is a bromodomain binding moiety, thereby modulating transcription of the gene in the cell.
Dependencies are inferred from the claim text.