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US 2024/0100141 A1Published application
T cell-directed anti-cancer vaccines against commensal viruses for treating mucosal carcinomas
AssigneeThe General Hospital Corporation
InventorShadmehr Demehri
Life of this patent
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Abstract
Immune-based approaches to treat and reduce the risk of cancer of mucosal tissues by boosting T cell immunity against commensal HPVs.
Claims23
A method of treating, or reducing the risk of developing, mucosal cancer in a subject, the method comprising administering to the subject an effective amount of a composition comprising:
- a plurality of (i) antigenic peptides, each comprising a sequence of 9-30 amino acids derived from proteins from commensal human papilloma viruses, or (ii) live or live-attenuated commensal human papilloma viruses;
- and
- a T cell adjuvant that increases T cell response to the antigenic peptides.
A composition comprising:
- a plurality of (i) antigenic peptides, each comprising a sequence of 9-30 amino acids derived from proteins from commensal human papilloma viruses, or (ii) live or live-attenuated commensal human papilloma viruses;
- and
- a T cell adjuvant that increases T cell response to the antigenic peptides.
Dependencies are inferred from the claim text.