Pharmaceutical composition for preventing or treating viral infections containing piperlongumine-based compound as active ingredient

A health functional food for preventing or ameliorating viral infections, containing a compound represented by the following Chemical Formula 1, and a pharmaceutically acceptable salt or solvate thereof as an active ingredient:

• wherein, in Chemical Formula 1,
• R2 to R4 are the same as or different from each other, and are each independently selected from the group consisting of hydrogen, deuterium, a halogen, a nitro group, a hydroxyl group, an amino group, a C1˜C40 alkyl group, a C2˜C40 alkenyl group, a C2˜C40 alkynyl group, a C3˜C4o cycloalkyl group, a heterocycloalkyl group having 3 to 40 nuclear atoms, a C1˜C20 alkoxy group, a C1˜C20 ketone group, a C1˜C20 ester group, a C6˜C20 aryl group, a heteroaryl group having 5 to 20 nuclear atoms, and a C6˜C20 aryloxy group, or these are optionally bonded to an adjacent group to form a C6˜C20 aryl or a heteroaryl ring having 5 to 20 nuclear atoms, provided that the case where R2 to R4 are the same is excluded,
• R1 is a substituent selected from the following structural formulae,
• in the formulae,
• the wavy part means a part that is bonded to Chemical Formula 1,
• X is a halogen element selected from the group consisting of F, Cl, Br and I,
• Y is a C1˜C10 alkyl group, and
• the alkyl group, the ketone group, the ester group, the aryl group, and the heteroaryl group of R2˜R4 are optionally each independently substituted with one or more substituents selected from the group consisting of deuterium, a halogen, a cyano group, a nitro group, a C1˜C40 alkyl group, a C2˜C40 alkenyl group, a C2˜C40 alkynyl group, a C6˜C40 aryl group, a heteroaryl group having 5 to 40 nuclear atoms, a C6˜C40 aryloxy group, a C1˜C40 alkyloxy group, a C6˜C40 arylamine group, a C3˜C40 cycloalkyl group, a heterocycloalkyl group having 3 to 40 nuclear atoms, a C1˜C40 alkylsilyl group, a C1˜C40 alkylboron group, a C6˜C40 arylboron group, a C6˜C40 arylphosphine group, a C6˜C40 arylphosphine oxide group and a C6˜C40 arylsilyl group, and in this case, when there is a plurality of substituents, the substituents are optionally the same as or different from each other.

A method for preventing, ameliorating or treating viral infections, the method comprising administering the compound represented by Chemical Formula 1, and a pharmaceutically acceptable salt or solvate thereof to an individual:

• wherein, in Chemical Formula 1,
• R2 to R4 are the same as or different from each other, and are each independently selected from the group consisting of hydrogen, deuterium, a halogen, a nitro group, a hydroxyl group, an amino group, a C1˜C40 alkyl group, a C2˜C40 alkenyl group, a C2˜C40 alkynyl group, a C3˜C4o cycloalkyl group, a heterocycloalkyl group having 3 to 40 nuclear atoms, a C1˜C20 alkoxy group, a C1˜C20 ketone group, a C1˜C20 ester group, a C6˜C20 aryl group, a heteroaryl group having 5 to 20 nuclear atoms, and a C6˜C20 aryloxy group, or these are optionally bonded to an adjacent group to form a C6˜C20 aryl or a heteroaryl ring having 5 to 20 nuclear atoms, provided that the case where R2 to R4 are the same is excluded,
• R1 is a substituent selected from the following structural formulae,
• in the formulae,
• the wavy part means a part that is bonded to Chemical Formula 1,
• X is a halogen element selected from the group consisting of F, Cl, Br and I,
• Y is a C1˜C10 alkyl group, and
• the alkyl group, the ketone group, the ester group, the aryl group, and the heteroaryl group of R2˜R4 are optionally each independently substituted with one or more substituents selected from the group consisting of deuterium, a halogen, a cyano group, a nitro group, a C1˜C40 alkyl group, a C2˜C40 alkenyl group, a C2˜C40 alkynyl group, a C6˜C40 aryl group, a heteroaryl group having 5 to 40 nuclear atoms, a C6˜C40 aryloxy group, a C1˜C40 alkyloxy group, a C6˜C40 arylamine group, a C3˜C40 cycloalkyl group, a heterocycloalkyl group having 3 to 40 nuclear atoms, a C1˜C40 alkylsilyl group, a C1˜C40 alkylboron group, a C6˜C40 arylboron group, a C6˜C40 arylphosphine group, a C6˜C40 arylphosphine oxide group and a C6˜C40 arylsilyl group, and in this case, when there is a plurality of substituents, the substituents are optionally the same as or different from each other.