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US 2024/0099997 A1Published application
Metalloenzyme modulators
OwnerAmbika Bhagi-Damodaran, Leonardo Rander Asse, Jr. +1inventors
InventorsAmbika Bhagi-Damodaran, Leonardo Rander Asse, Jr., Sourav Chatterjee
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Abstract
Disclosed herein are methods to inhibit a metalloprotein and methods to treat diseases and crop infections with a compound of formula I: X-L-Y I or a salt thereof. Also disclosed are novel compounds of formula I or a salt thereof and compositions comprising a compound of formula I.
Claims20
A method to inhibit a metalloprotein comprising contacting the metalloprotein with a compound of formula I:
- X-L-Y I
- or a salt thereof, wherein:
- X is nitrile (—CN), hydrazine, —SCN, —NCS, or —OCN;
- L is a linker or L is absent;
- and
- Y is a moiety that binds to a gas tunnel or a substrate tunnel of the metalloprotein.
3 more elements
Dependencies are inferred from the claim text.