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US 2024/0093034 A1Published application
Fluorescent dyes
AssigneeExopharm Limited
InventorsJim PALMER, Ian DIXON, Patrick JAMES, Melanie SCHOPPET, Karmen KONG, Sebastian M. MARCUCCIO, Jonathan M. FABER, Kieran P. STOCKTON, Melissa WERRETT, Rohan JOYCE
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Abstract
The present invention relates to fluorescent dyes of formula (I), including salts thereof, and extracellular vesicles and cells labelled with the fluorescent dyes. The present invention also relates to methods, uses and kits thereof.
Claims29
The EV of claim 1, wherein
- R1 is selected from C13-26alkyl, C13-26alkenyl and C13-26heteroalkyl;
- R2 is selected from C1-6alkyl, C1-6heteroalkyl, C1-6alkyl-OH and C1-6heteroalkyl-OH;
- and
- R3, R4, R5 and R6 are each independently C1-6alkyl or C1-6haloalkyl.
1 more element
A salt of a compound of formula (II):
- wherein
- R1 is selected from optionally substituted C13-26aliphatic, C13-26heteroaliphatic comprising 1 or 2 heteroatoms in the longest linear heteroaliphatic chain, optionally substituted C13-26aliphatic-OH, optionally substituted C13-26heteroaliphatic-OH and OH;
- R2 is selected from optionally substituted C1-6aliphatic, optionally substituted C1-6heteroaliphatic, optionally substituted C1-6aliphatic-OH, optionally substituted C1-6heteroaliphatic-OH, and OH;
- R3, R4, R5 and R6 are independently selected from optionally substituted C1-6alkyl, optionally substituted C1-6haloalkyl, optionally substituted aryl and optionally substituted C1-6alkylaryl or
- R3 and R4 together with the nitrogen atom to which they are attached form an optionally substituted 3-7 membered heterocyclic ring;
- and/or
- R3 and R4 together with the nitrogen atom to which they are attached form an optionally substituted 3-7 membered heterocyclic ring;
- and
- RA, RB, RC and RD are independently selected from a hydrogen, fluorine and chlorine;
- and
- X− is selected from fluoride, chloride, bromide, iodide, acetate, trifluoroacetate, benzoate, C1-26alkyl sulfonate, arylsulfonate, nitrate, hexafluorophosphate, tetrafluoroborate, trichlorozincate(II), tetrachloroferrate and perchlorate.
8 more elements
Dependencies are inferred from the claim text.