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OwnerHikaru KOGA, Reiji TERAMOTO +2inventors
InventorsHikaru KOGA, Reiji TERAMOTO, Shouichi METSUGI, Taro KAKUZAKI
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The invention relates to antibodies such as anti-C1 s antibodies, pharmaceutical compositions comprising the same, and methods of using the same. The invention provides antibodies that comprise an antigen-binding region and an antibody constant region, have a displacement function such that the antibody binds to C1qrs complex and promotes dissociation of C1q from C1qrs complex and/or a blocking function such that the antibody binds to C1r2s2 and inhibits the binding of C1q to C1r2s2, and bind to C1s in a pH-dependent manner. The invention also provides pharmaceutical compositions comprising any one of the antibodies, and methods of treating an individual having a complement-mediated disease or disorder, or preventing an individual potentially having a complement-mediated disease or disorder, comprising administering any one of the antibodies to the individual.
An isolated antibody that comprises an antigen-binding region and an antibody constant region, wherein:
An isolated anti-C1s antibody that comprises a heavy chain variable region, a light chain variable region and an antibody constant region, wherein the heavy chain variable region comprising HVR-H1 comprising an amino acid sequence consisting of AYAMN (SEQ ID NO:
Dependencies are inferred from the claim text.