Methods and compositions for pertussis diagnosis

An isolated antibody or antigen binding fragment thereof immunologically specific for tracheal colonization factor A (TcfA), wherein said antibody or fragment thereof specifically binds amino acids 140-160, amino acids 229-240, amino acids 288-304, amino acids 286-321, amino acids 289-324, amino acids 305-323, amino acids 322-330, or amino acids 337-345 of TcfA.