Patient-specific brachytherapy applicators

A system for delivery of radiation therapy comprising:

• an applicator, wherein the applicator comprises a housing, wherein the housing defines channels configured to guide brachytherapy catheters wherein the housing is configured to receive a source of radiation, and wherein the housing defines identification chambers;
• shielding configured to protect a recipient from radiation generated by the source of radiation;
• wherein the applicator, the channel, and the shielding are configured and customized to provide the radiation therapy in accordance with an imaging and radiation treatment plan and wherein the channels and shielding are placed in a customized configuration based on the radiation treatment plan;
• a real-time tracking system comprising:
• a tracking device;
• imaging markers disposed in the applicator to localize the applicator for image-based treatment planning and for image-guided treatment delivery;
• and,
• localizing landmarks.