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AssigneeNIRvana Sciences Inc.
InventorsJames Bruce Pitner, Russell D. Thomas, Joshua O. Akhigbe
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Provided are photoacoustic imaging contrast agents that include at least one radiation-absorbing component comprising a copper-complexed and/or manganese-complexed chlorin and/or bacteriochlorin and/or a derivative thereof, or a combination thereof. Also provided are methods for using the disclosed photoacoustic imaging contrast agents either singly or in combination for generating an image of a volume, optionally a subject or a body part, cell, tissue, or organ thereof. Further provided are compositions and methods for multiplex photoacoustic imaging of a volume, optionally a subject or a body part, cell, tissue, or organ thereof using photoacoustic imaging contrast agents that include a plurality of the presently disclosed copper-complexed and/or manganese-complexed chlorins and/or bacteriochlorins and/or derivatives thereof simultaneously.
A photoacoustic imaging contrast agent comprising at least one radiation-absorbing component, wherein the at least one radiation-absorbing component comprises a metallobacteriochlorin, a metallochlorin, a derivative thereof, or any combination thereof, wherein the metallobacteriochlorin, the metallochlorin, or the derivative thereof is complexed to copper or manganese.
A method of generating an image of a volume, the method comprising:
A method for multiplex photoacoustic imaging of a volume, the method comprising:
The method of claim 27, wherein the volume comprises a tumor cell, a cancer cell, or a tumor- or cancer-associated vascular cell.
A photoacoustic imaging contrast agent comprising at least one radiation-absorbing component comprising a metallobacteriochlorin and/or the derivative thereof, or a combination thereof, wherein the at least one radiation-absorbing component comprises a compound selected from the group consisting of MBC-1, MBC-2, MBC-3, and MBC-2-PEG, wherein MBC-1, MBC-2, MBC-3, and MBC-2-PEG have the following structures:
A method for preparing a PEGylated Cu-bacteriochlorin, the method comprising treating a free base PEGylated bacteriochlorin with copper acetate and sodium hydride in dimethylformmamide (DMF) under conditions sufficient to produce the PEGylated Cu-bacteriochlorin.
Dependencies are inferred from the claim text.