Back to results
US 2024/0082425 A1Published application
Lipid structures and compositions comprising same
AssigneeTurn Biotechnologies, Inc.
InventorsMouhannad Jumaa, Zeeshan Kamal, Dipti Barman
Life of this patent
Estimating the term…
Abstract
The disclosure relates to ionizable lipids and compositions comprising the ionizable lipids. Lipid-nanoparticle compositions comprised of an ionizable lipid, optionally in combination with other lipid components such as helper lipids, stabilization lipids and structural lipids, and a therapeutic agent, such as a nucleic acid, for delivery to mammalian cells or organs are described.
Claims30
-47. (canceled)
A compound having the following structure of Formula (XVII):
- or a stereoisomer, salt or tautomer thereof, wherein:
- G1 and G2 are each independently —OC(═O)—, —NR25C(═O)—, or —CH═CH—;
- R21 and R22 are each independently C1-C6 alkyl, linear C10-C20 alkyl, linear C10-C20 alkenyl, or branched C10-C35 alkenyl, wherein the C1-C6 alkyl is substituted with —OC(═O)R26;
- R23 is H, OH, or OCH3;
- R24 is C1-C8 heteroalkyl;
- R25 is H or C1-C4 alkyl;
- R26 is branched C10-C30 alkyl;
- and
- m1 and m2 are each independently an integer of 0 or 1.
6 more elements
(canceled)
(canceled)
(canceled)
-62. (canceled)
-69. (canceled)
-98. (canceled)
(canceled)
-139. (canceled)
Dependencies are inferred from the claim text.