Methods for Enhancing Efficacy of a Vaccine by Administering an IL-4R Antagonist
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsLisa Purcell, Neil Graham, Andrew J. Murphy, Robert Evans
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Abstract
The present invention provides methods for enhancing the efficacy and/or safety of a vaccine. In certain embodiments, the invention provides methods to increase or potentiate the immune response to a vaccine in a subject in need thereof. The methods of the present invention comprise administering to a subject in need thereof an interleukin-4 receptor (IL-4R) antagonist such as an anti-IL-4R antibody in combination with said vaccine. In certain embodiments, the methods of the present invention are used to afford enhanced protection to an infectious disease such as whooping cough.
Claims22
1-114. (canceled)
A method for increasing the T helper 1 (Th1) immune response of a subject to a vaccine that elicits a T helper 2 (Th2) type immune response, the method comprising administering to the subject one or more doses of an interleukin-4 receptor (IL-4R) antagonist before or concurrently with an initial dose of the vaccine;
- wherein the IL-4R antagonist is an antibody or antigen-binding fragment thereof that binds IL-4Rα, wherein the antibody or antigen-binding fragment thereof comprises the heavy chain complementarity determining regions (HCDRs) of a heavy chain variable region (HCVR) comprising the amino acid sequence of SEQ ID NO:
- 1 and the light chain complementarity determining regions (LCDRs) of a light chain variable region (LCVR) comprising the amino acid sequence of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.