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US 2024/0076645 A1Published application
Bacteria engineered to reduce hyperphenylalaninemia
AssigneeSynlogic Operating Company, Inc.
InventorsDean Falb, Vincent M. Isabella, Jonathan W. Kotula, Paul F. Miller, Sarah Rowe, Yves Millet
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Abstract
Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating diseases associated with hyperphenylalaninemia are disclosed.
Claims19
-48. (canceled)
A nucleic acid sequence comprising
- (a) one or more gene(s) encoding a phenylalanine ammonia lyase (PAL) comprising an amino acid sequence having at least 90% identity with SEQ ID NO:
- 3, wherein the gene(s) encoding the PAL is operably linked a promoter selected from the group consisting of a promoter that is induced under low-oxygen or anaerobic conditions;
- a thermoregulated promoter;
- and a promoter that is induced by arabinose, thiogalactopyranoside (IPTG), tetracycline, or rhamnose;
- and
- (b) one or more gene(s) encoding a phenylalanine transporter comprising an amino acid sequence having at least 90% identity with SEQ ID NO:
- 60, wherein the gene(s) encoding the phenylalanine transporter is operably linked to a thiogalactopyranoside (IPTG)-inducible promoter.
4 more elements
Dependencies are inferred from the claim text.