Compositions and methods for culturing and expanding cells
AssigneeLife Technologies Corporation
InventorsAngel VARELA-ROHENA, Jennifer DONATO, Sarya MANSOUR, Matthew DALLAS, Anna-Barbara HACHMANN
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Abstract
Provided herein are, inter alia, compositions, systems, kits, and methods for culturing and expanding cells (such as T cells, diploid or non-diploid cells), as well as methods for treating disorders (e.g., with T cells), and methods for producing biological molecules and compositions (e.g., proteins, viruses, viral particles or fragments thereof, etc.), including vaccines.
Claims29
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A combination comprising (i) a population of T cells and (ii) a culture medium that comprises a cyclodextrin and at least one lipid.
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A method for culturing a T cell population, the method comprising incubating the population in a cell culture medium comprising a cyclodextrin and at least one lipid.
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A method of culturing a T cell population that comprises CD8+ T cells and CD4+ T cells while increasing the ratio of CD8+ T cells to CD4+ T cells within the population, the method comprising incubating the population in a cell culture medium comprising 2-deoxy-D-glucose.
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Dependencies are inferred from the claim text.