Cxcl10 binding proteins and uses thereof
AssigneeHudson Institute of Medical Research
InventorsAndrew N. Stephens, Adam Rainczuk, Sung-Woog Kang
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Abstract
The present invention relates to C-X-C motif chemokine ligand 10 (CXCL10) binding proteins and uses thereof. The present invention also relates to methods of detecting and/or diagnosing a condition in a subject, comprising determining a level of CXCL10 in the subject.
Claims31
A C-X-C motif chemokine ligand 10 (CXCL10) binding protein, wherein the binding protein binds to full-length human CXCL10, N-terminally truncated CXCL10 and citrullinated CXCL10.
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A method of detecting and/or diagnosing a malignant condition in a subject, the method comprising:
- (i) determining a level of active CXCL10 in the subject and a level of total CXCL10 in the subject;
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- (ii) determining a CXCL10 ratio of active CXCL10 CXLC10 to total CXCL10 in the subject;
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- (iii) detecting and/or diagnosing the maliganant condition in the subject based on the level determined in (i) and (ii)
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Dependencies are inferred from the claim text.