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US 2024/0076340 A1Published application
Il-15-based fusions to il-7 and il-21
AssigneeAltor BioScience Corporation
InventorHing C. Wong
Life of this patent
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Abstract
The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-7 or IL-21.
Claims7
1-60. (canceled)
An isolated soluble fusion protein complex comprising at least two soluble proteins, wherein:
- a first soluble protein comprises an interleukin-15 (IL-15) polypeptide domain and an IL-7 domain according to SEQ ID NO:4, and
- a second soluble protein comprises an IL-21 polypeptide domain and an IL-15 receptor alpha sushi-binding domain (IL-15RαSu) fused to an immunoglobulin Fc domain according to SEQ ID NO:2, wherein the IL-15 domain of the first soluble protein binds to the IL-15RαSu domain of the second soluble protein to form a soluble fusion protein complex.
Dependencies are inferred from the claim text.