Barriers including cross-linked amphiphilic molecules, and methods of making the same
AssigneeIllumina Cambridge Limited
InventorsAntonio Conde-Gonzalez, Charlotte Vacogne, Istvan Kocsis, Alexandre Richez, Oliver Uttley, Miguel Angel Aleman Garcia, Yuliia Vyborna
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Abstract
Barriers including crosslinked amphiphilic molecules, and methods of making the same, are provided herein. In some examples, a barrier between first and second fluids includes at least one layer comprising a plurality of amphiphilic molecules. Amphiphilic molecules of the plurality of amphiphilic molecules are crosslinked to one another.
Claims21
A barrier between first and second fluids, the barrier comprising:
- at least one layer comprising a plurality of amphiphilic molecules,
- wherein amphiphilic molecules of the plurality of amphiphilic molecules are crosslinked to one another.
The barrier of claim 1, wherein the amphiphilic molecules are crosslinked by a product of a coupling reaction. (Original) The barrier of claim 14, wherein the coupling reaction comprises a thiol-ene click reaction, a thiol-yne click reaction, a strain-promoted alkyne-azide cycloaddition, an amide coupling, a thiol/aza-Michael reaction, a [2+2] cycloaddition, a thio-Michael click reaction, a condensation reaction, a [2+2] photocycloaddition, a protein-ligand interaction, host-guest chemistry, a disulfide formation, an imine formation, or an enamine formation.
A barrier between first and second fluids, the barrier comprising:
- at least one layer comprising a plurality of amphiphilic molecules,
- wherein the amphiphilic molecules comprise reactive moieties to perform a crosslinking reaction with one another.
20-33. (canceled)
A method of forming a barrier between first and second fluids, the method comprising:
- forming at least one layer comprising a plurality of amphiphilic molecules, wherein the amphiphilic molecules comprise reactive moieties;
- using crosslinking reactions of the reactive moieties to crosslink amphiphilic molecules of the plurality to one another.
35-59. (canceled)
Dependencies are inferred from the claim text.