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AssigneeBoston Scientific Scimed, Inc.
InventorsJoseph Thomas Delaney, JR., Yen-Hao Hsu, Tatyana Dyndikova
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In various aspects, the present disclosure pertains to systems for forming hydrogels that comprise an iodinated polyamino compound and a reactive multi-arm polymer that comprises a plurality of hydrophilic polymer arms having reactive end groups that are reactive with amino groups of the iodinated polyamino compound. Other aspects of the present disclosure pertain to medical hydrogels that are formed by crosslinking the iodinated polyamino compound and the reactive multi-arm polymer of such systems. Further aspects of the present disclosure pertain to medical procedures that can be performed using such systems. Still other aspects of the present disclosure pertain to methods of making iodinated polyamino compounds.
A system for forming a hydrogel that comprises an iodinated polyamino compound and a reactive multi-arm polymer that comprises a plurality of hydrophilic polymer arms having reactive end groups that are reactive with amino groups of the iodinated polyamino compound.
A method of treatment comprising administering to a subject a mixture that comprises an iodinated polyamino compound and a reactive multi-arm polymer that comprises a plurality of hydrophilic polymer arms having reactive end groups that are reactive with amino groups of the iodinated polyamino compound under conditions such that the iodinated polyamino compound and the reactive multi-arm polymer cross-link after administration.
A method of making an iodinated polyamino compound comprising (a) forming a protected carboxyl-substituted polyamino compound by protecting amino groups of the carboxyl-substituted polyamino compound, (b) forming an amide linkage between the carboxyl group of the protected carboxyl-substituted polyamino compound and an amino group of an iodinated amino acid compound, and (c) deprotecting amino groups of the product of step (b).
Dependencies are inferred from the claim text.